The Calcium-sensing receptor directly regulates proximal tubular functions (Commentary on: Calcium sensing receptor modulates fluid reabsorption and H- secretion in the proximal tubule by Capasso et al.)

Capasso et al. show a role of the calcium-sensing receptor (CaSR) in enhancing proximal tubular fluid absorption and urinary acidification by stimulation of luminal Na(+)/H(+) exchanger (NHE) activity. NHE3 is required for sodium and fluid absorption, and its activity is coupled to passive reabsorption of a major fraction of calcium through the paracellular route. These data shed new light on the regulation of the kidney by the CaSR and whether it directly affects proximal tubular functions. DOI: https://doi.org/10.1038/ki.2013.128 Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-81039 Originally published at: Wagner, Carsten A The calcium-sensing receptor directly regulates proximal tubular functions. Edited by: Wagner, Carsten Alexander (2013). Kidney Int. 2013: Nature Publishing Group. DOI: https://doi.org/10.1038/ki.2013.128